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Peripheral Nerve Suicide Transport Generates a Reproducible SCI

Unlike many organs in the body, the brain and spinal cord are unable to promote regeneration. The brain has a limited capacity for adaptive plasticity, but lacks functional replacement of injured, diseased or damaged neural parenchyma. Novel approaches to treat CNS lesions are required, as current therapies are solely palliative and do not generate repair. Essentially all clinical breakthroughs come from pre-clinical research where the fundamental principal for scientific advancement is experimental reproducibility. We describe a simple and reproducible pre-clinical model of spinal cord injury that can provide a platform to develop strategies to promote neural repair and regeneration.


Joanna E Pagano, Allison S Liang, Christopher A Chrzan and Randall D Mckinnon

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